First Domestic Time-of-Flight Mass Spectrometer Enters Clinical Application

[China Instrument Network Instrument Development] Recently, the first time-of-flight mass spectrometer (Clin-ToF) independently developed in China passed the demonstration of Peking Union Medical College Hospital and has now officially entered the clinical laboratory of the hospital for clinical use. The research and development of this product shows that China has made significant progress in the development of mass spectrometers.


According to the experimental comparison of the Department of Clinical Laboratory of Peking Union Medical College Hospital, this home-made mass spectrometer has the same efficacy as the internationally recognized Bruker mass spectrometry system in the detection of gram-negative bacteria. In response, Xu Yingchun, director of the inspection department of Peking Union Medical College Hospital, said that this shows that domestically produced mass spectrometers with independent intellectual property rights have reached international advanced levels in certain specific bacterial detection fields.

It is understood that this advanced mass spectrometer, which can perform comprehensive research on bacterial proteomes and genomes, was developed by Yixin Bochuang. In 2012, it passed the European CEIVD certification and in 2014 passed the certification of China Food and Drug Administration. It can rapidly detect and identify gram-negative bacteria, which are common pathogenic microorganisms that cause diarrhea, pneumonia, and wound infections in humans.

According to reports, gram-negative bacteria are the collective name of various bacteria, including Shigella, Klebsiella, influenza (Hemophilus) bacillus, Bordetella pertussis and other pathogenic bacteria, and the use of mass spectrometry to test bacteria is a new technology in the field of laboratory medicine . This detection device can accurately and quickly identify the resistance of pathogenic bacteria in a patient.

The papers written according to this evaluation experiment have been published in the Chinese Journal of Laboratory Medicine recently.

(Original title: China's first bacterial inspection mass spectrometer entered the clinical application)

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